The nicotinic acetylcholine receptor: from molecular model to single-channel conductance.

The nicotinic acetylcholine receptor: from molecular model to single-channel conductance.

The nicotinic acetylcholine receptor (nAChR) is the archetypal ligand-gated ion channel. A model of the alpha7 homopentameric nAChR is described in which the pore-lining M2 helix bundle is treated atomistically and the remainder of the molecule is treated as a "low resolution" cylinder. Th...

Полное описание

Библиографические подробности
Главные авторы:	Adcock, C, Smith, G, Sansom, MS
Формат:	Journal article
Язык:	English
Опубликовано:	2000

Схожие документы

The pore domain of the nicotinic acetylcholine receptor: molecular modeling, pore dimensions, and electrostatics
по: Sankararamakrishnan, R, и др.
Опубликовано: (1996)

A hydrophobic gate in an ion channel: the closed state of the nicotinic acetylcholine receptor.
по: Beckstein, O, и др.
Опубликовано: (2006)

The alpha7 nicotinic acetylcholine receptor: molecular modelling, electrostatics, and energetics.
по: Amiri, S, и др.
Опубликовано: (2005)

Molecular dynamics study of water and Na⁺ ions in models of the pore region of the nicotinic acetylcholine receptor
по: Smith, G, и др.
Опубликовано: (1997)

Mechanics of channel gating of the nicotinic acetylcholine receptor.
по: Xinli Liu, и др.
Опубликовано: (2008-01-01)

Novel alpha7-like nicotinic acetylcholine receptor subunits in the nematode Caenorhabditis elegans.
по: Mongan, N, и др.
Опубликовано: (2002)

Nicotinic acetylcholine receptors and epilepsy
по: Andrea Becchetti, и др.
Опубликовано: (2023-03-01)

Alcohol and nicotinic acetylcholine receptors
по: Jinsong Tang, и др.
Опубликовано: (2013-05-01)

Molecular recognition of the neurotransmitter acetylcholine by an acetylcholine binding protein reveals determinants of binding to nicotinic acetylcholine receptors.
по: Jeppe A Olsen, и др.
Опубликовано: (2014-01-01)

Structural studies of acetylcholine bound to the nicotinic acetylcholine receptor
по: Williamson, P, и др.
Опубликовано: (2003)

Neuronal nicotinic acetylcholine receptors: Common molecular substrates of nicotine and alcohol dependence
по: Linzy M. Hendrickson, и др.
Опубликовано: (2013-04-01)

Regulation of nicotinic acetylcholine receptor assembly.
по: Wanamaker, C, и др.
Опубликовано: (2003)

Distinctive single-channel properties of α4β2-nicotinic acetylcholine receptor isoforms.
по: Maegan M Weltzin, и др.
Опубликовано: (2019-01-01)

Nicotinic Acetylcholine Receptors in the Respiratory Tract
по: Monika I. Hollenhorst, и др.
Опубликовано: (2021-10-01)

Autoimmunity to neuronal nicotinic acetylcholine receptors
по: Maria Pechlivanidou, и др.
Опубликовано: (2023-06-01)

Impulsive Behavior and Nicotinic Acetylcholine Receptors
по: Yu Ohmura, и др.
Опубликовано: (2012-01-01)

Evolution of vertebrate nicotinic acetylcholine receptors
по: Julia E. Pedersen, и др.
Опубликовано: (2019-01-01)

Molecular dynamics simulation of the M2 helices within the nicotinic acetylcholine receptor transmembrane domain: structure and collective motions.
по: Hung, A, и др.
Опубликовано: (2005)

Polyamine regulation of ion channel assembly and implications for nicotinic acetylcholine receptor pharmacology
по: Madhurima Dhara, и др.
Опубликовано: (2020-06-01)

Nicotinic Acetylcholine Receptors in Glial Cells as Molecular Target for Parkinson’s Disease
по: Érica Novaes Soares, и др.
Опубликовано: (2024-03-01)

An Inside Job: Molecular Determinants for Postsynaptic Localization of Nicotinic Acetylcholine Receptors
по: Michael Ferns
Опубликовано: (2021-05-01)

Discovery of the First Neurotransmitter Receptor: The Acetylcholine Nicotinic Receptor
по: Jean-Pierre Changeux
Опубликовано: (2020-04-01)

Conotoxins Targeting Nicotinic Acetylcholine Receptors: An Overview
по: Eline K. M. Lebbe, и др.
Опубликовано: (2014-05-01)

Nicotinic acetylcholine receptors in neurological and psychiatric diseases
по: Alvin V. Terry, Jr., и др.
Опубликовано: (2023-05-01)

Signaling of nicotinic acetylcholine receptors in mononuclear phagocytes
по: Katrin Richter, и др.
Опубликовано: (2023-05-01)

A novel congenital myasthenic syndrome due to decreased acetylcholine receptor ion-channel conductance
по: Webster, R, и др.
Опубликовано: (2012)

A novel congenital myasthenic syndrome due to decreased acetylcholine receptor ion-channel conductance.
по: Webster, R, и др.
Опубликовано: (2012)

Somatic integration of single ion channel responses of α7 nicotinic acetylcholine receptors enhanced by PNU-120596.
по: Victor V Uteshev
Опубликовано: (2012-01-01)

Association between nicotinic acetylcholine receptor single nucleotide polymorphisms and smoking cessation.
по: Spruell, T, и др.
Опубликовано: (2012)

Pathogenesis of Abdominal Aortic Aneurysms: Role of Nicotine and Nicotinic Acetylcholine Receptors
по: Zong-Zhuang Li, и др.
Опубликовано: (2012-01-01)

Neurotransmitter regulation of neural development: acetylcholine and nicotinic receptors
по: TORRÃO ANDRÉA S., и др.
Опубликовано: (2002-01-01)

The conformation of acetylcholine at its target site in the membrane-embedded nicotinic acetylcholine receptor.
по: Williamson, P, и др.
Опубликовано: (2007)

Nicotinic acetylcholine receptors mediate lung cancer growth
по: Ma. Reina eImprogo, и др.
Опубликовано: (2013-09-01)

The fourth transmembrane domain of the muscle nicotinic acetylcholine receptor epsilon subunit is not required for channel function
по: Beeson, D, и др.
Опубликовано: (2000)

Neuronal Nicotinic Acetylcholine Receptor Modulators from Cone Snails
по: Nikita Abraham, и др.
Опубликовано: (2018-06-01)

Regulation of Dopamine Release by Striatal Acetylcholine and Nicotine Is via Distinct Nicotinic Acetylcholine Receptors in Dorsal vs. Ventral Striatum
по: Exley, R, и др.
Опубликовано: (2009)

Nicotinic Acetylcholine Receptor (nAChR) Dependent Chorda Tympani Taste Nerve Responses to Nicotine, Ethanol and Acetylcholine.
по: Zuo Jun Ren, и др.
Опубликовано: (2015-01-01)

Molecular determinants for competitive inhibition of alpha4beta2 nicotinic acetylcholine receptors.
по: Iturriaga-Vásquez, P, и др.
Опубликовано: (2010)

Neuronal Nicotinic Acetylcholine Receptors: Neuroplastic Changes underlying Alcohol and Nicotine Addictions
по: Allison Anne Feduccia, и др.
Опубликовано: (2012-08-01)

The muscle-type nicotinic acetylcholine receptor in health and disease
по: Cetin, H
Опубликовано: (2019)