Expression of guanylyl cyclase-B (GC-B/NPR2) receptors in normal human fetal pituitaries and human pituitary adenomas implicates a role for C-type natriuretic peptide.

C-type natriuretic peptide (CNP/Nppc) is expressed at high levels in the anterior pituitary of rats and mice and activates guanylyl cyclase B receptors (GC-B/Npr2) to regulate hormone secretion. Mutations in NPR2/Npr2 can cause achondroplasia, GH deficiency, and female infertility, yet the normal ex...

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Bibliographic Details
Main Authors:	Thompson, I, Chand, A, King, P, Ansorge, O, Karavitaki, N, Jones, C, Rahmutula, D, Gardner, D, Zivkovic, V, Wheeler-Jones, C, McGonnell, I, Korbonits, M, Anderson, R, Wass, J, McNeilly, A, Fowkes, R
Format:	Journal article
Language:	English
Published:	2012

Expression of guanylyl cyclase-B (GC-B/NPR2) receptors in normal human fetal pituitaries and human pituitary adenomas implicates a role for C-type natriuretic peptide.

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