Rabbit atherosclerotic lesions express scavenger receptor AIII mRNA, a naturally occurring splice variant that encodes a non-functional, dominant negative form of the macrophage scavenger receptor.

Macrophage class A scavenger receptor types I and II (SR-AI and II) mediate the uptake of oxidized LDL in atherosclerotic lesions. The recently described type III receptor (SR-AIII), which lacks amino acids encoded by exon 10 of the SR-A gene, is unable to mediate the uptake of ligands and acts as a...

詳細記述

書誌詳細
主要な著者: Hiltunen, T, Gough, P, Greaves, D, Gordon, S, Ylä-Herttuala, S
フォーマット: Journal article
言語:English
出版事項: 2001