Generation and site-directed mutagenesis of a 35K-Fc fusion protein with increased potency of CC chemokine blockade

Generation and site-directed mutagenesis of a 35K-Fc fusion protein with increased potency of CC chemokine blockade

Bibliografiske detaljer
Main Authors:	White, G, McNeill, E, Channon, K, Greaves, D
Format:	Conference item
Udgivet:	2010

Lignende værker

Site-directed mutagenesis of the CC chemokine binding protein 35K-Fc reveals residues essential for activity and mutations that increase the potency of CC chemokine blockade.
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Hydrodynamic gene delivery of CC chemokine binding Fc fusion proteins to target acute vascular inflammation in vivo.
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Expression of a membrane associated CC-chemokine inhibitor protein reduces in vitro macrophage chemotaxis to CC chemokines
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Membrane-bound CC chemokine inhibitor 35K provides localized inhibition of CC chemokine activity in vitro and in vivo.
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A membrane-bound vaccinia viral protein 'mem35k' blocks CC-chemokine induced cell migration and CC-chemokine activity in vitro
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Adenoviral delivery of CC-chemokine inhibitor '35K' reduces macrophage recruitment and atherosclerosis in ApoE knockout mice
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Adenoviral mediated delivery of a vaccinia viral protein (35K) blocks CC-chemokine activity in vitro and in vivo and may therefore be a useful therapeutic strategy to reduce the initiation and progression of CC-chemokine induced atherosclerosis
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Udgivet: (2003)

Adenoviral-mediated delivery of a CC-chemokine inhibitor ('35K') attenuates atherosclerotic plaque formation in apolipoprotein E-knockout mice
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Adenoviral delivery of a Cc-chemokine inhibitor, "35k," reduces macrophage recruitment and atherosclerosis in Apoe knockout mice
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Adenoviral mediated delivery of a CC chemokine (CK) inhibitor ("35K") attenuates atherosclerotic plaque formation in apolipoprotein E-knockout mice
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Contrasting in vitro vs. in vivo effects of a cell membrane-specific CC-chemokine binding protein on macrophage chemotaxis.
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Lentiviral gene transfer to reduce atherosclerosis progression by long-term CC-chemokine inhibition.
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Broad-spectrum CC-chemokine blockade by gene transfer inhibits macrophage recruitment and atherosclerotic plaque formation in apolipoprotein E-knockout mice.
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Adenoviral-mediated delivery of a viral chemokine binding protein blocks CC-chemokine activity in vitro and in vivo.
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Broad spectrum adenoviral CC-chemokine blockade attenuates long term vein graft accelerated atherosclerosis in ApoE-knockout mice
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Adenoviral gene transfer of a broad spectrum CC-chemokine inhibitor reduces vein graft atherosclerosis in apolipoprotein E-knockout mice
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Site-Directed Mutagenesis by Fusion of Contiguous DNA Fragments
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Gene transfer of a broad spectrum CC-chemokine inhibitor reduces macrophage recruitment and smooth muscle content in vein graft atherosclerosis in apolipoprotein E-knockout mice
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Fractalkine promotes human monocyte survival via a reduction in oxidative stress.
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