Generation and site-directed mutagenesis of a 35K-Fc fusion protein with increased potency of CC chemokine blockade

Generation and site-directed mutagenesis of a 35K-Fc fusion protein with increased potency of CC chemokine blockade

Sonraí bibleagrafaíochta
Príomhchruthaitheoirí:	White, G, McNeill, E, Channon, K, Greaves, D
Formáid:	Conference item
Foilsithe / Cruthaithe:	2010

Míreanna comhchosúla

Site-directed mutagenesis of the CC chemokine binding protein 35K-Fc reveals residues essential for activity and mutations that increase the potency of CC chemokine blockade.
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Adenoviral mediated delivery of a vaccinia viral protein (35K) blocks CC-chemokine activity in vitro and in vivo and may therefore be a useful therapeutic strategy to reduce the initiation and progression of CC-chemokine induced atherosclerosis
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