Analysis of somatic molecular changes, clinicopathological features, family history, and germline mutations in colorectal cancer families: evidence for efficient diagnosis of HNPCC and for the existence of distinct groups of non-HNPCC families.

Analysis of somatic molecular changes, clinicopathological features, family history, and germline mutations in colorectal cancer families: evidence for efficient diagnosis of HNPCC and for the existence of distinct groups of non-HNPCC families.

OBJECTIVE: To analyse somatic molecular changes, clinicopathological features, family history, and germline mutations in families with colorectal cancer (CRC). METHODS: Molecular changes (K-ras and beta-catenin mutations, chromosome 18q allele loss (LOH), APC LOH, microsatellite instability (MSI), a...

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Bibliographic Details
Main Authors: Johnson, V, Lipton, L, Cummings, C, Eftekhar Sadat, A, Izatt, L, Hodgson, S, Talbot, I, Thomas, H, Silver, A, Tomlinson, I
Format: Journal article
Language:English
Published: 2005

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