A triazole linkage that mimics the DNA phosphodiester group in living systems
We describe the development of a chemical process based on the CuAAC reaction (click chemistry) to ligate DNA strands and produce an unnatural triazole backbone linkage. The chemical reaction is templated by a complementary DNA splint which accelerates the reaction and provides the required specific...
| Main Authors: | , |
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| Format: | Journal article |
| Language: | English |
| Published: |
Cambridge University Press
2015
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