C9orf72-ALS human iPSC microglia are pro-inflammatory and toxic to co-cultured motor neurons via MMP9

C9orf72-ALS human iPSC microglia are pro-inflammatory and toxic to co-cultured motor neurons via MMP9

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterized by progressive motor neuron loss, with additional pathophysiological involvement of non-neuronal cells such as microglia. The commonest ALS-associated genetic variant is a hexanucleotide repeat expansion (HRE) mutation...

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Váldodahkkit: Vahsen, BF, Nalluru, S, Morgan, G, Farrimond, L, Carroll, E, Xu, Y, Cramb, K, Amein, B, Scaber, J, Katsikoudi, A, Candalija, A, Carcole, M, Dafinca, R, Isaacs, A, Wade-Martins, R, Gray, E, Turner, M, Cowley, S, Talbot, K
Materiálatiipa: Journal article
Giella:English
Almmustuhtton: Springer Nature 2023

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