Transcriptional signature of human pro-inflammatory TH17 cells identifies reduced IL10 gene expression in multiple sclerosis.

Transcriptional signature of human pro-inflammatory TH17 cells identifies reduced IL10 gene expression in multiple sclerosis.

We have previously reported the molecular signature of murine pathogenic TH17 cells that induce experimental autoimmune encephalomyelitis (EAE) in animals. Here we show that human peripheral blood IFN-γ+IL-17+ (TH1/17) and IFN-γ-IL-17+ (TH17) CD4+ T cells display distinct transcriptional profiles in...

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Bibliografski detalji
Glavni autori: Hu, D, Notarbartolo, S, Croonenborghs, T, Patel, B, Cialic, R, Yang, T, Aschenbrenner, D, Andersson, K, Gattorno, M, Pham, M, Kivisakk, P, Pierre, I, Lee, Y, Kiani, K, Bokarewa, M, Tjon, E, Pochet, N, Sallusto, F, Kuchroo, V, Weiner, H
Format: Journal article
Jezik:English
Izdano: Nature Publishing Group 2017

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