Cellular confocal fluorescence studies and cytotoxic activity of new Zn(II) bis(thiosemicarbazonato) complexes.
We report the synthesis and characterisation of new, highly fluorescent, zinc complexes of bis(thiosemicarbazone) ligands incorporating extended aromatic backbones which are cytotoxic at levels comparable to cisplatin; cellular fluorescence imaging studies suggest these cause cell death by disruptio...
| Main Authors: | , , , , , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
2008
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| _version_ | 1797085656053186560 |
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| author | Pascu, S Waghorn, P Conry, T Lin, B Betts, H Dilworth, JR Sim, R Churchill, G Aigbirhio, F Warren, J |
| author_facet | Pascu, S Waghorn, P Conry, T Lin, B Betts, H Dilworth, JR Sim, R Churchill, G Aigbirhio, F Warren, J |
| author_sort | Pascu, S |
| collection | OXFORD |
| description | We report the synthesis and characterisation of new, highly fluorescent, zinc complexes of bis(thiosemicarbazone) ligands incorporating extended aromatic backbones which are cytotoxic at levels comparable to cisplatin; cellular fluorescence imaging studies suggest these cause cell death by disruption of mitochondria. |
| first_indexed | 2024-03-07T02:11:34Z |
| format | Journal article |
| id | oxford-uuid:a0d305f3-5cb3-429c-88b9-5ddd647907dc |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T02:11:34Z |
| publishDate | 2008 |
| record_format | dspace |
| spelling | oxford-uuid:a0d305f3-5cb3-429c-88b9-5ddd647907dc2022-03-27T02:08:25ZCellular confocal fluorescence studies and cytotoxic activity of new Zn(II) bis(thiosemicarbazonato) complexes.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:a0d305f3-5cb3-429c-88b9-5ddd647907dcEnglishSymplectic Elements at Oxford2008Pascu, SWaghorn, PConry, TLin, BBetts, HDilworth, JRSim, RChurchill, GAigbirhio, FWarren, JWe report the synthesis and characterisation of new, highly fluorescent, zinc complexes of bis(thiosemicarbazone) ligands incorporating extended aromatic backbones which are cytotoxic at levels comparable to cisplatin; cellular fluorescence imaging studies suggest these cause cell death by disruption of mitochondria. |
| spellingShingle | Pascu, S Waghorn, P Conry, T Lin, B Betts, H Dilworth, JR Sim, R Churchill, G Aigbirhio, F Warren, J Cellular confocal fluorescence studies and cytotoxic activity of new Zn(II) bis(thiosemicarbazonato) complexes. |
| title | Cellular confocal fluorescence studies and cytotoxic activity of new Zn(II) bis(thiosemicarbazonato) complexes. |
| title_full | Cellular confocal fluorescence studies and cytotoxic activity of new Zn(II) bis(thiosemicarbazonato) complexes. |
| title_fullStr | Cellular confocal fluorescence studies and cytotoxic activity of new Zn(II) bis(thiosemicarbazonato) complexes. |
| title_full_unstemmed | Cellular confocal fluorescence studies and cytotoxic activity of new Zn(II) bis(thiosemicarbazonato) complexes. |
| title_short | Cellular confocal fluorescence studies and cytotoxic activity of new Zn(II) bis(thiosemicarbazonato) complexes. |
| title_sort | cellular confocal fluorescence studies and cytotoxic activity of new zn ii bis thiosemicarbazonato complexes |
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