trans-2,5-Disubstituted pyrrolidines: Rapid stereocontrolled access from sulfones.
A direct and versatile route for the reliable synthesis of trans-2,5-disubstituted pyrrolidines from pyroglutamic acid is reported, which can be conducted at scale and without chromatographic purification of key intermediates.
| Main Authors: | , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
2006
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