Interdomain conformational changes provide allosteric regulation en route to chorismate

Multifunctional proteins play a variety of roles in metabolism. Here we examine the catalytic function of the combined 3-deoxy-D-arabino heptulosonate 7-phosphate synthase (DAH7PS) and chorismate mutase (CM) from Geobacillus sp. DAH7PS operates at the start of the biosynthetic pathway for aromatic m...

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Bibliographic Details
Main Authors: Nazmi, A, Lang, E, Bai, Y, Allison, T, Othman, M, Panjikar, S, Arcus, V, Parker, E
Format: Journal article
Language:English
Published: American Society for Biochemistry and Molecular Biology 2016