Apomine, an inhibitor of HMG-CoA-reductase, promotes apoptosis of myeloma cells in vitro and is associated with a modulation of myeloma in vivo.

Apomine, an inhibitor of HMG-CoA-reductase, promotes apoptosis of myeloma cells in vitro and is associated with a modulation of myeloma in vivo.

Apomine, a novel 1,1 bisphosphonate ester, increases the rate of degradation of HMG-CoA reductase, inhibiting the mevalonate pathway and thereby blocking cholesterol biosynthesis. We have investigated whether Apomine can induce myeloma cell apoptosis in vitro and modulate myeloma disease in vivo. Ap...

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Détails bibliographiques
Auteurs principaux: Edwards, C, Mueller, G, Roelofs, A, Chantry, A, Perry, M, Russell, R, Van Camp, B, Guyon-Gellin, Y, Niesor, E, Bentzen, C, Vanderkerken, K, Croucher, P
Format: Journal article
Langue:English
Publié: 2007

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