Apomine, an inhibitor of HMG-CoA-reductase, promotes apoptosis of myeloma cells in vitro and is associated with a modulation of myeloma in vivo.

Apomine, an inhibitor of HMG-CoA-reductase, promotes apoptosis of myeloma cells in vitro and is associated with a modulation of myeloma in vivo.

Apomine, a novel 1,1 bisphosphonate ester, increases the rate of degradation of HMG-CoA reductase, inhibiting the mevalonate pathway and thereby blocking cholesterol biosynthesis. We have investigated whether Apomine can induce myeloma cell apoptosis in vitro and modulate myeloma disease in vivo. Ap...

Бүрэн тодорхойлолт

Номзүйн дэлгэрэнгүй
Үндсэн зохиолчид:	Edwards, C, Mueller, G, Roelofs, A, Chantry, A, Perry, M, Russell, R, Van Camp, B, Guyon-Gellin, Y, Niesor, E, Bentzen, C, Vanderkerken, K, Croucher, P
Формат:	Journal article
Хэл сонгох:	English
Хэвлэсэн:	2007

Ижил төстэй зүйлс

Apomine, an inhibitor of HMG-COA-reductase, does not act by inhibiting protein prenylation in human myeloma cells in vitro
-н: Roelofs, A, зэрэг
Хэвлэсэн: (2005)

APOMINE (TM), a novel inhibitor of the meyalonate/isoprenoid pathway, promotes apoptosis of myeloma cells in vitro and is associated with a modulation of the myeloma disease in vivo.
-н: Croucher, P, зэрэг
Хэвлэсэн: (2002)

Apomine enhances the antitumor effects of lovastatin on myeloma cells by down-regulating 3-hydroxy-3-methylglutaryl-coenzyme A reductase.
-н: Roelofs, A, зэрэг
Хэвлэсэн: (2007)

Novel insights into the anti-tumour mechanism of action of apomine and its synergistic interaction with lovastatin in myeloma cells in vitro
-н: Roelofs, A, зэрэг
Хэвлэсэн: (2006)

Bisphosphonates and osteoprotegerin as inhibitors of myeloma bone disease.
-н: Croucher, P, зэрэг
Хэвлэсэн: (2003)

HMG CoA reductase inhibitors in the treatment of hypercholesterolaemias.
-н: Aronson, J, зэрэг
Хэвлэсэн: (1990)

Pleiotropic effects of the HMG-CoA reductase inhibitors
-н: Mihos CG, зэрэг
Хэвлэсэн: (2011-04-01)

Regulation of HMG-CoA reductase activity in plants.
-н: B A Stermer, зэрэг
Хэвлэсэн: (1994-07-01)

Activation of HMG-CoA reductase by microsomal phosphatase
-н: K R Feingold, зэрэг
Хэвлэсэн: (1983-03-01)

HMG-CoA reductase kinase: measurement of activity by methods that preclude interference by inhibitors of HMG-CoA reductase activity or by mevalonate kinase.
-н: H J Harwood, Jr, зэрэг
Хэвлэсэн: (1982-07-01)

Myeloma cells can promote osteoclastic activity rather than osteoclast recruitment in vitro; Evidence from the 5T2MM murine model of myeloma
-н: Mueller, G, зэрэг
Хэвлэсэн: (2004)

5T2MM murine myeloma cells and CD138+ve human myeloma cells promote osteoclastic activity rather than osteoclast formation in vitro
-н: Mueller, G, зэрэг
Хэвлэсэн: (2004)

Bisphosphonates--mechanisms of action in multiple myeloma.
-н: Shipman, C, зэрэг
Хэвлэсэн: (2000)

The potent bisphosphonate ibandronate does not induce myeloma cell apoptosis in a murine model of established multiple myeloma.
-н: Shipman, C, зэрэг
Хэвлэсэн: (2000)

HMG CoA reductase of intestinal mucosa and liver of the rat
-н: S. Shefer, зэрэг
Хэвлэсэн: (1972-05-01)

Osteoprotegerin and the development of myeloma bone disease
-н: Croucher, P, зэрэг
Хэвлэсэн: (2004)

Genetic and dietary interactions in the regulation of HMG-CoA reductase gene expression.
-н: JJ Hwa, зэрэг
Хэвлэсэн: (1992-05-01)

The prenyltransferase UBIAD1 is the target of geranylgeraniol in degradation of HMG CoA reductase
-н: Marc M Schumacher, зэрэг
Хэвлэсэн: (2015-03-01)

Bisphosphonates and in vivo models of multiple myeloma - Reply
-н: Shipman, C, зэрэг
Хэвлэсэн: (2001)

QSAR Regression Models for Predicting HMG-CoA Reductase Inhibition
-н: Robert Ancuceanu, зэрэг
Хэвлэсэн: (2024-10-01)

HMG-CoA Reductase Inhibitors from Monascus-Fermented Rice
-н: Xuemei Li, зэрэг
Хэвлэсэн: (2013-01-01)

Eupatilin Alleviates Hyperlipidemia in Mice by Inhibiting HMG-CoA Reductase
-н: Kyung-Joo Kim, зэрэг
Хэвлэсэн: (2023-01-01)

The role of HMG-CoA reductase inhibition in endothelial dysfunction and inflammation
-н: Paolo Gelosa, зэрэг
Хэвлэсэн: (2007-11-01)

Induction of HMG CoA reductase by the administration of 20,25-diazacholesterol
-н: R Langdon, зэрэг
Хэвлэсэн: (1977-01-01)

MTD–CoMSIA modelling of HMG-CoA reductase inhibitors
-н: DANIEL M. DUDA-SEIMAN, зэрэг
Хэвлэсэн: (2011-01-01)

Measurement of human leukocyte microsomal HMG-CoA reductase activity.
-н: H J Harwood, Jr, зэрэг
Хэвлэсэн: (1984-09-01)

Osteoprotegerin inhibits the development of osteolytic bone disease in multiple myeloma
-н: Croucher, P, зэрэг
Хэвлэсэн: (2001)

Atorvastatin action involves diminished recovery of hepatic HMG-CoA reductase activity
-н: Gene C. Ness, зэрэг
Хэвлэсэн: (1998-01-01)

Mutations within the membrane domain of HMG-CoA reductase confer resistance to sterol-accelerated degradation
-н: Peter C.W. Lee, зэрэг
Хэвлэсэн: (2007-02-01)

Rapid reverse phase-HPLC assay of HMG-CoA reductase activity
-н: Matteo Mozzicafreddo, зэрэг
Хэвлэсэн: (2010-08-01)

Targeting Enterococcus faecalis HMG-CoA reductase with a non-statin inhibitor
-н: Sucharita Bose, зэрэг
Хэвлэсэн: (2023-04-01)

Regulated degradation of HMG CoA reductase requires conformational changes in sterol-sensing domain
-н: Hongwen Chen, зэрэг
Хэвлэсэн: (2022-07-01)

Are Point Mutations in HMG-CoA Reductases (Hmg1 and Hmg2) a Step towards Azole Resistance in <i>Aspergillus fumigatus</i>?
-н: Irene Gonzalez-Jimenez, зэрэг
Хэвлэсэн: (2021-10-01)

Lepidopteran HMG-CoA reductase is a potential selective target for pest control
-н: Yuan-mei Li, зэрэг
Хэвлэсэн: (2017-01-01)

An Atomic-Level Perspective of HMG-CoA-Reductase: The Target Enzyme to Treat Hypercholesterolemia
-н: Diana S. Gesto, зэрэг
Хэвлэсэн: (2020-08-01)

Effects of HMG-CoA Reductase Inhibitors (Statins) On Bone Mineral Density and Metabolism
-н: Nehir Samancı, зэрэг
Хэвлэсэн: (2004-06-01)

Molecular docking studies of Triphala with catalytic portion of HMG-CoA reductase enzyme
-н: Prasoborn Rinthong, зэрэг
Хэвлэсэн: (2023-04-01)

Influence of simvA glyzin on expression and inhibition of hmg-coa reductase in rats liver
-н: Yu. I. Ragino, зэрэг
Хэвлэсэн: (2015-06-01)

Hesperidin Interaction with HMG-CoA-Reductase Enzyme in Hypercholesterolemia: A Study in Silico
-н: Annisa Rizqi Dwi Oktaviani, зэрэг
Хэвлэсэн: (2021-09-01)

HMG-CoA reductase III. Abstracts. June 4, 1983, San Francisco.
Хэвлэсэн: (1983-10-01)