Molecular monitoring of the Leu-164 mutation of dihydrofolate reductase in a highly sulfadoxine/pyrimethamine-resistant area in Africa.

Molecular monitoring of the Leu-164 mutation of dihydrofolate reductase in a highly sulfadoxine/pyrimethamine-resistant area in Africa.

The selection of point mutation at codon 164 (from isoleucine to leucine) of the dihydrofolate reductase (DHFR) enzyme in Plasmodium falciparum is associated with high sulfadoxine /pyrimethamine (SP) resistance. Using the yeast expression system that allows the detection of dhfr allele present at lo...

Deskribapen osoa

Xehetasun bibliografikoak
Egile Nagusiak:	Ochong, E, Nzila, A, Kimani, S, Kokwaro, G, Mutabingwa, T, Watkins, W, Marsh, K
Formatua:	Journal article
Hizkuntza:	English
Argitaratua:	BioMed Central 2003

Antzeko izenburuak

Why has the dihydrofolate reductase 164 mutation not consistently been found in Africa yet?
nork: Nzila, A, et al.
Argitaratua: (2005)

Dihydrofolate reductase mutations in Plasmodium vivax from Indonesia and therapeutic response to sulfadoxine plus pyrimethamine.
nork: Hastings, MD, et al.
Argitaratua: (2004)

Effects of point mutations in Plasmodium falciparum dihydrofolate reductase and dihydropterate synthase genes on clinical outcomes and in vitro susceptibility to sulfadoxine and pyrimethamine.
nork: David J Bacon, et al.
Argitaratua: (2009-08-01)

Analysis of sulphadoxine/pyrimethamine resistance-conferring mutations of <it>Plasmodium falciparum </it>from Mozambique reveals the absence of the dihydrofolate reductase 164L mutant
nork: Cravo Pedro, et al.
Argitaratua: (2007-03-01)

Dihydrofolate Reductase I164L Mutation in Plasmodium falciparum, Madagascar
nork: Didier Ménard, et al.
Argitaratua: (2008-07-01)

Frequencies distribution of dihydrofolate reductase and dihydropteroate synthetase mutant alleles associated with sulfadoxine-pyrimethamine resistance in Plasmodium falciparum population from Hadhramout Governorate, Yemen
nork: Bamaga, O.A.A., et al.
Argitaratua: (2015)

Declining trend of Plasmodium falciparum dihydrofolate reductase (dhfr) and dihydropteroate synthase (dhps) mutant alleles after the withdrawal of Sulfadoxine-Pyrimethamine in North Western Ethiopia.
nork: Sofonias K Tessema, et al.
Argitaratua: (2015-01-01)

Sulfadoxine-pyrimethamine for the treatment of malaria.
nork: White, N
Argitaratua: (1991)

"Pyrimethamine and Proguanil Resistance-Conferring Key Mutations in Dihydrofolate Reductase Gene of Plasmodium falciparum Isolates from Iran"
nork: AA Eskandarian, et al.
Argitaratua: (2003-12-01)

Evidence of Pyrimethamine and Cycloguanil Analogues as Dual Inhibitors of <i>Trypanosoma brucei</i> Pteridine Reductase and Dihydrofolate Reductase
nork: Giusy Tassone, et al.
Argitaratua: (2021-06-01)

Sulfadoxine-pyrimethamine pharmacokinetics in malaria: pediatric dosing implications.
nork: Barnes, K, et al.
Argitaratua: (2006)

Artesunate-, sulfadoxine-, and pyrimethamine-induced cardiotoxicity
nork: Divya Goel, et al.
Argitaratua: (2016-01-01)

Comparative efficacy of chloroquine and pyrimethamine-sulfadoxine versus artemether and pyrimethamine-sulfadoxine in the treatment of uncomplicated falciparum malaria in children
nork: Femmy Tambajong, et al.
Argitaratua: (2016-10-01)

Spatiotemporal spread of Plasmodium falciparum mutations for resistance to sulfadoxine-pyrimethamine across Africa, 1990-2020.
nork: Jennifer A Flegg, et al.
Argitaratua: (2022-08-01)

The role of sequential administration of sulphadoxine/pyrimethamine following quinine in the treatment of severe falciparum malaria in children.
nork: Ogutu, B, et al.
Argitaratua: (2005)

Chloroquine and Sulfadoxine–Pyrimethamine Resistance in Sub-Saharan Africa—A Review
nork: Alexandra T. Roux, et al.
Argitaratua: (2021-06-01)

Evaluation of dihydrofolate reductase and dihydropteroate synthetase genotypes that confer resistance to sulphadoxine-pyrimethamine in <it>Plasmodium falciparum</it> in Haiti
nork: Carter Tamar E, et al.
Argitaratua: (2012-08-01)

Qinghaosu, mefloquine, and pyrimethamine-sulfadoxine in falciparum malaria.
nork: Peto, T, et al.
Argitaratua: (1985)

Widespread resistance mutations to sulfadoxine-pyrimethamine in malaria parasites imported to China from Central and Western Africa
nork: Luyi Zhao, et al.
Argitaratua: (2020-04-01)

Therapeutic efficacy of sulfadoxine-pyrimethamine, amodiaquine and the sulfadoxine-pyrimethamine-amodiaquine combination against uncomplicated Plasmodium falciparum malaria in young children in Cameroon
nork: Basco Leonardo K., et al.
Argitaratua: (2002-01-01)

Evaluation of Dihydrofolate Reductase (Dhfr) Gene, Related to Plasmodium Falciparum Pyrimethamine Resistance in Imported Malaria Cases in Iran
nork: Seyyed Ali Shariatzadeh, et al.
Argitaratua: (2021-11-01)

Randomized trial of artesunate+amodiaquine, sulfadoxine-pyrimethamine+amodiaquine, chlorproguanal-dapsone and SP for malaria in pregnancy in Tanzania.
nork: Theonest K Mutabingwa, et al.
Argitaratua: (2009-01-01)

A roadmap for understanding sulfadoxine-pyrimethamine in malaria chemoprevention
nork: Thiery Masserey, et al.

Assessment of the Teratogenic Effect of Sulfadoxine-Pyrimethamine on the Chicken Embryo
nork: Rachida Moussa Tari, et al.
Argitaratua: (2022-01-01)

Prevention of malaria in pregnancy: The threat of sulfadoxine-pyrimethamine resistance
nork: Sesh A. Sundararaman, et al.
Argitaratua: (2022-08-01)

Combination of probenecid-sulphadoxine-pyrimethamine for intermittent preventive treatment in pregnancy
nork: Gutman Julie, et al.
Argitaratua: (2012-02-01)

Plasmodium falciparum resistance to sulfadoxine-pyrimethamine in Africa: a systematic analysis of national trends
nork: Floriano Amimo, et al.
Argitaratua: (2020-11-01)

A single dose of intramuscular sulfadoxine-pyrimethamine as an adjunct to quinine in the treatment of severe malaria: pharmacokinetics and efficacy.
nork: Newton, C, et al.
Argitaratua: (1993)

Stable high frequencies of sulfadoxine–pyrimethamine resistance associated mutations and absence of K13 mutations in Plasmodium falciparum 3 and 4 years after the introduction of artesunate plus sulfadoxine–pyrimethamine in Ujjain, Madhya Pradesh, India
nork: Ashish Pathak, et al.
Argitaratua: (2020-08-01)

Sulfadoxine/Pyrimethamine Intermittent Preventive Treatment for Malaria during Pregnancy
nork: Philippe Deloron, et al.
Argitaratua: (2010-11-01)

Association of genetic mutations in Plasmodium vivax dhfr with resistance to sulfadoxine-pyrimethamine: geographical and clinical correlates.
nork: Imwong, M, et al.
Argitaratua: (2001)

Intermittent presumptive treatment in pregnancy with sulfadoxine-pyrimethamine: A counter perspective
nork: Nosten, F, et al.
Argitaratua: (2015)

Intermittent preventive treatment in pregnancy with sulfadoxine-pyrimethamine: the times they are a-changin'.
nork: Harrington, W, et al.
Argitaratua: (2012)

Intermittent preventive treatment in pregnancy with sulfadoxine-pyrimethamine: the times they are a-changin'
nork: Harrington, W, et al.
Argitaratua: (2014)

Ab initio study of opto electric properties of the molecules pyrimethamine and sulfadoxine
nork: S. Nouemo, et al.
Argitaratua: (2015-10-01)

Uptake and Effectiveness of Intermittent Preventive Treatment with Sulfadoxine-Pyrimethamine during Pregnancy in Africa: A Scoping Review
nork: Gifty Osei Berchie, et al.
Argitaratua: (2024-09-01)

Multiple origins of resistance-conferring mutations in <it>Plasmodium vivax dihydrofolate reductase</it>
nork: O'Neil Michael T, et al.
Argitaratua: (2008-04-01)

The binding of trimethoprim to bacterial dihydrofolate reductase.
nork: Baker, D, et al.
Argitaratua: (1981)

Adaptations for Pressure and Temperature in Dihydrofolate Reductases
nork: Ryan W. Penhallurick, et al.
Argitaratua: (2021-08-01)

The data presented by Jelinek et al. (1997) should not be taken as evidence against an association between resistance to sulphadoxine-pyrimethamine (S/P) and mutations in the dihydrofolate reductase gene of Plasmodium falciparum.
nork: White, N
Argitaratua: (1998)