Molecular monitoring of the Leu-164 mutation of dihydrofolate reductase in a highly sulfadoxine/pyrimethamine-resistant area in Africa.

The selection of point mutation at codon 164 (from isoleucine to leucine) of the dihydrofolate reductase (DHFR) enzyme in Plasmodium falciparum is associated with high sulfadoxine /pyrimethamine (SP) resistance. Using the yeast expression system that allows the detection of dhfr allele present at lo...

पूर्ण विवरण

ग्रंथसूची विवरण
मुख्य लेखकों: Ochong, E, Nzila, A, Kimani, S, Kokwaro, G, Mutabingwa, T, Watkins, W, Marsh, K
स्वरूप: Journal article
भाषा:English
प्रकाशित: BioMed Central 2003