Differential selection pressure exerted on HIV by CTL targeting identical epitopes but restricted by distinct HLA alleles from the same HLA supertype.

Differential selection pressure exerted on HIV by CTL targeting identical epitopes but restricted by distinct HLA alleles from the same HLA supertype.

HLA diversity is seen as a major challenge to CTL vaccines against HIV. One current approach focuses on "promiscuous" epitopes, presented by multiple HLA alleles from within the same HLA supertype. However, the effectiveness of such supertype vaccines depends upon the functional equivalenc...

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Dettagli Bibliografici
Autori principali: Leslie, A, Price, D, Mkhize, P, Bishop, K, Rathod, A, Day, C, Crawford, H, Honeyborne, I, Asher, T, Luzzi, G, Edwards, A, Rousseau, C, Rosseau, C, Mullins, J, Tudor-Williams, G, Novelli, V, Brander, C, Douek, D, Kiepiela, P, Walker, B, Goulder, P
Natura: Journal article
Lingua:English
Pubblicazione: 2006

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