An integrated hypothesis that considers drusen as biomarkers of immune-mediated processes at the RPE-Bruch's membrane interface in aging and age-related macular degeneration.

Age-related macular degeneration (AMD) is a blinding disease that afflicts millions of adults in the Western world. Although it has been proposed that a threshold event occurs during normal aging which leads to AMD, the sequelae of biochemical, cellular, and/or molecular events leading to the develo...

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Bibliographic Details
Main Authors: Hageman, G, Luthert, P, Victor Chong, N, Johnson, L, Anderson, D, Mullins, R
Format: Journal article
Language:English
Published: 2001