Early treatment failure in severe malaria resulting from abnormally low plasma quinine concentrations.

A patient admitted with severe Plasmodium falciparum malaria in western Thailand had an early treatment failure with quinine, despite full dosing. Plasma quinine concentrations were subtherapeutic. Abnormal quinine pharmacokinetics may explain sporadic reports of quinine treatment failures in severe...

Disgrifiad llawn

Manylion Llyfryddiaeth
Prif Awduron: Newton, P, Ward, S, Angus, B, Chierakul, W, Dondorp, A, Ruangveerayuth, R, Silamut, K, Teerapong, P, Suputtamongkol, Y, Looareesuwan, S, White, N
Fformat: Journal article
Iaith:English
Cyhoeddwyd: 2006
Disgrifiad
Crynodeb:A patient admitted with severe Plasmodium falciparum malaria in western Thailand had an early treatment failure with quinine, despite full dosing. Plasma quinine concentrations were subtherapeutic. Abnormal quinine pharmacokinetics may explain sporadic reports of quinine treatment failures in severe malaria.