Investigating molecular mechanisms underlying Marfan syndrome, based on fibrillin-1 secretion and assembly
<p>Fibrillin-1 is a major glycoprotein component of 10-12 nm microfibrils, consisting predominantly of calcium binding epidermal factor-like (cbEGF) and TGFß binding protein like (TB) domains. Mutations within the gene encoding fibrillin-1 cause Marfan Syndrome (MFS), an autosomal dominant dis...
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| Format: | Thesis |
| Language: | English |
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2020
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