Defective ALC1 nucleosome remodeling confers PARPi sensitization and synthetic lethality with HRD

Chromatin is a barrier to efficient DNA repair, as it hinders access and processing of certain DNA lesions. ALC1/CHD1L is a nucleosome-remodeling enzyme that responds to DNA damage, but its precise function in DNA repair remains unknown. Here we report that loss of ALC1 confers sensitivity to PARP i...

Full description

Bibliographic Details
Main Authors:	Hewitt, G, Borel, V, Segura-Bayona, S, Takaki, T, Ruis, P, Bellelli, R, Lehmann, LC, Sommerova, L, Vancevska, A, Tomas-Loba, A, Zhu, K, Cooper, C, Fugger, K, Patel, H, Goldstone, R, Schneider-Luftman, D, Herbert, E, Stamp, G, Brough, R, Pettitt, S, Lord, CJ, West, SC, Ahel, I, Ahel, D, Chapman, JR, Deindl, S, Boulton, SJ
Format:	Journal article
Language:	English
Published:	Cell Press 2020

Defective ALC1 nucleosome remodeling confers PARPi sensitization and synthetic lethality with HRD

Similar Items