Defective ALC1 nucleosome remodeling confers PARPi sensitization and synthetic lethality with HRD
Chromatin is a barrier to efficient DNA repair, as it hinders access and processing of certain DNA lesions. ALC1/CHD1L is a nucleosome-remodeling enzyme that responds to DNA damage, but its precise function in DNA repair remains unknown. Here we report that loss of ALC1 confers sensitivity to PARP i...
Main Authors: | Hewitt, G, Borel, V, Segura-Bayona, S, Takaki, T, Ruis, P, Bellelli, R, Lehmann, LC, Sommerova, L, Vancevska, A, Tomas-Loba, A, Zhu, K, Cooper, C, Fugger, K, Patel, H, Goldstone, R, Schneider-Luftman, D, Herbert, E, Stamp, G, Brough, R, Pettitt, S, Lord, CJ, West, SC, Ahel, I, Ahel, D, Chapman, JR, Deindl, S, Boulton, SJ |
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Format: | Journal article |
Language: | English |
Published: |
Cell Press
2020
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