Genetic variation at the 8q24.21 renal cancer susceptibility locus affects HIF binding to a MYC enhancer

Genetic variation at the 8q24.21 renal cancer susceptibility locus affects HIF binding to a MYC enhancer

Clear cell renal cell carcinoma (ccRCC) is characterized by loss of function of the von Hippel-Lindau tumour suppressor (VHL) and unrestrained activation of hypoxia-inducible transcription factors (HIFs). Genetic and epigenetic determinants have an impact on HIF pathways. A recent genome-wide associ...

Полное описание

Библиографические подробности
Главные авторы:	Grampp, S, Platt, J, Lauer, V, Salama, R, Kranz, F, Neumann, V, Wach, S, Stöhr, C, Hartmann, A, Eckardt, K, Ratcliffe, P, Mole, D, Schödel, J
Формат:	Journal article
Язык:	English
Опубликовано:	Nature Publishing Group 2016

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