Dual catalytic enantioselective desymmetrization of allene-tethered cyclohexanones

The construction of enantioenriched azabicyclo[3.3.1]nonan-6-one heterocycles via an enantioselective desymmetrization of allene-linked cyclohexanones, enabled through a dual catalytic system, that provides synchronous activation of the cyclohexanone with a chiral prolinamide and the allene with a c...

Full description

Bibliographic Details
Main Authors: Zhang, L, Yamazaki, K, Leitch, JA, Manzano, R, Atkinson, AM, Hamlin, TA, Dixon, DJ
Format: Journal article
Language:English
Published: Royal Society of Chemistry 2020