Quantitative mass spectrometry reveals dynamics of factor-inhibiting hypoxia-inducible factor-catalyzed hydroxylation

The asparaginyl hydroxylase, factor-inhibiting hypoxia-inducible factor(HIF), is central to the oxygen-sensing pathway that controls the activity of HIF. Factor-inhibiting HIF (FIH) also catalyzes the hydroxylation of a large set of proteins that share a structural motif termed the ankyrin repeat do...

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Bibliographic Details
Main Authors: Singleton, R, Trudgian, D, Fischer, R, Kessler, B, Ratcliffe, P, Cockman, M
Format: Journal article
Language:English
Published: 2011