Characterization and differential nuclear localization of Nopp140 and a novel Nopp140-like protein in trypanosomes.
Trypanosomatids possess two homologues of Nopp140: a canonical Nopp140 and a Nopp140-like protein (TbNoLP) in which a GAR domain replaces the C-terminal SRP40 domain. Both are phosphorylated and coimmunoprecipitate with RNA polymerase I. Each paralogue has a distinct subnuclear localization, and dep...
| Main Authors: | , , , , |
|---|---|
| Format: | Journal article |
| Jezik: | English |
| Izdano: |
2006
|
| _version_ | 1826288522497097728 |
|---|---|
| author | Kelly, S Singleton, W Wickstead, B Ersfeld, K Gull, K |
| author_facet | Kelly, S Singleton, W Wickstead, B Ersfeld, K Gull, K |
| author_sort | Kelly, S |
| collection | OXFORD |
| description | Trypanosomatids possess two homologues of Nopp140: a canonical Nopp140 and a Nopp140-like protein (TbNoLP) in which a GAR domain replaces the C-terminal SRP40 domain. Both are phosphorylated and coimmunoprecipitate with RNA polymerase I. Each paralogue has a distinct subnuclear localization, and depletion of TbNoLP produces an enlarged nucleolus in which TbNopp140-containing regions disperse. The restricted occurrence pattern of NoLP proteins reflects an intriguing convergence in evolution, suggestive of a function in nucleoplasmic small nucleolar ribonucleoprotein shuttling. |
| first_indexed | 2024-03-07T02:14:58Z |
| format | Journal article |
| id | oxford-uuid:a1e8b9b6-f48c-4549-9864-1d8c4fdb3525 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T02:14:58Z |
| publishDate | 2006 |
| record_format | dspace |
| spelling | oxford-uuid:a1e8b9b6-f48c-4549-9864-1d8c4fdb35252022-03-27T02:16:35ZCharacterization and differential nuclear localization of Nopp140 and a novel Nopp140-like protein in trypanosomes.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:a1e8b9b6-f48c-4549-9864-1d8c4fdb3525EnglishSymplectic Elements at Oxford2006Kelly, SSingleton, WWickstead, BErsfeld, KGull, KTrypanosomatids possess two homologues of Nopp140: a canonical Nopp140 and a Nopp140-like protein (TbNoLP) in which a GAR domain replaces the C-terminal SRP40 domain. Both are phosphorylated and coimmunoprecipitate with RNA polymerase I. Each paralogue has a distinct subnuclear localization, and depletion of TbNoLP produces an enlarged nucleolus in which TbNopp140-containing regions disperse. The restricted occurrence pattern of NoLP proteins reflects an intriguing convergence in evolution, suggestive of a function in nucleoplasmic small nucleolar ribonucleoprotein shuttling. |
| spellingShingle | Kelly, S Singleton, W Wickstead, B Ersfeld, K Gull, K Characterization and differential nuclear localization of Nopp140 and a novel Nopp140-like protein in trypanosomes. |
| title | Characterization and differential nuclear localization of Nopp140 and a novel Nopp140-like protein in trypanosomes. |
| title_full | Characterization and differential nuclear localization of Nopp140 and a novel Nopp140-like protein in trypanosomes. |
| title_fullStr | Characterization and differential nuclear localization of Nopp140 and a novel Nopp140-like protein in trypanosomes. |
| title_full_unstemmed | Characterization and differential nuclear localization of Nopp140 and a novel Nopp140-like protein in trypanosomes. |
| title_short | Characterization and differential nuclear localization of Nopp140 and a novel Nopp140-like protein in trypanosomes. |
| title_sort | characterization and differential nuclear localization of nopp140 and a novel nopp140 like protein in trypanosomes |
| work_keys_str_mv | AT kellys characterizationanddifferentialnuclearlocalizationofnopp140andanovelnopp140likeproteinintrypanosomes AT singletonw characterizationanddifferentialnuclearlocalizationofnopp140andanovelnopp140likeproteinintrypanosomes AT wicksteadb characterizationanddifferentialnuclearlocalizationofnopp140andanovelnopp140likeproteinintrypanosomes AT ersfeldk characterizationanddifferentialnuclearlocalizationofnopp140andanovelnopp140likeproteinintrypanosomes AT gullk characterizationanddifferentialnuclearlocalizationofnopp140andanovelnopp140likeproteinintrypanosomes |