Recombinational switching of the Clostridium difficile S-layer and a novel glycosylation gene cluster revealed by large-scale whole-genome sequencing.

Recombinational switching of the Clostridium difficile S-layer and a novel glycosylation gene cluster revealed by large-scale whole-genome sequencing.

BACKGROUND: Clostridium difficile is a major cause of nosocomial diarrhea, with 30-day mortality reaching 30%. The cell surface comprises a paracrystalline proteinaceous S-layer encoded by the slpA gene within the cell wall protein (cwp) gene cluster. Our purpose was to understand the diversity and...

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Bibliographic Details
Main Authors: Dingle, K, Didelot, X, Ansari, M, Eyre, D, Vaughan, A, Griffiths, D, Ip, C, Batty, E, Golubchik, T, Bowden, R, Jolley, K, Hood, D, Fawley, W, Walker, A, Peto, T, Wilcox, M, Crook, D
Format: Journal article
Language:English
Published: 2013

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