Hydroxymethyl-Branched Piperidines from Hydroxymethyl-Branched Lactones: Synthesis and Biological Evaluation of 1,5-Dideoxy-2-C-hydroxymethyl-1,5-imino-D-mannitol, 1,5-Dideoxy-2-C-hydroxymethyl-1,5-imino-L-gulitol and 1,5-Dideoxy-2-C-hydroxymethyl-1,5-imino-D-talitol

Three homochiral polyhydroxylated piperidines containing a quaternary carbon branch at C-2 of the heterocyclic ring, which can be considered as branched analogues of deoxymannorijimycin (DMJ), and their corresponding lactams were synthesised from readily available and versatile carbohydrate lactones...

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Hlavní autoři: Soengas, R, Simone, M, Hunter, S, Nash, R, Evinson, E, Fleet, G
Médium: Journal article
Jazyk:English
Vydáno: 2012