HLA-DR/DQ haplotype in rheumatoid arthritis: novel allelic associations in UK Caucasians.
OBJECTIVE: To elucidate the relative importance of the HLA-DR and HLA-DQ loci in conferring genetic predisposition to rheumatoid arthritis (RA). METHODS: HLA-DRB1 and HLA-DQB1 alleles were typed in a set of 685 patients with RA using sequence-specific polymerase chain reaction. Allele and phenotype...
| Główni autorzy: | , , , , |
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| Format: | Journal article |
| Język: | English |
| Wydane: |
2002
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| _version_ | 1826288648366063616 |
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| author | Milicic, A Lee, D Brown, M Darke, C Wordsworth, B |
| author_facet | Milicic, A Lee, D Brown, M Darke, C Wordsworth, B |
| author_sort | Milicic, A |
| collection | OXFORD |
| description | OBJECTIVE: To elucidate the relative importance of the HLA-DR and HLA-DQ loci in conferring genetic predisposition to rheumatoid arthritis (RA). METHODS: HLA-DRB1 and HLA-DQB1 alleles were typed in a set of 685 patients with RA using sequence-specific polymerase chain reaction. Allele and phenotype frequencies were compared with those in 2 large sets of historical, ethnically matched healthy controls, using the relative predispositional effect method. RESULTS: Positive association was confirmed with the shared epitope positive HLA-DRB1 alleles associated with RA in Caucasians. A significant susceptibility effect was observed with HLA-DRB1*09, described in other ethnically diverse populations but not in Caucasians. A significant underrepresentation of the HLA-DRB1*0103 variant was noted among the RA cases, supporting the proposed protective role of the DERAA motif at residues 70-74 of the DRbeta molecule. No HLA-DRB1 independent association of the HLA-DQB1 alleles, implicated in predisposing to RA, was evident. CONCLUSION: These data corroborate the shared epitope hypothesis of susceptibility to RA and provide strong evidence for the DRB1 locus as the primary RA susceptibility factor in the HLA region. |
| first_indexed | 2024-03-07T02:16:53Z |
| format | Journal article |
| id | oxford-uuid:a28de22e-43a4-4844-a39e-a2f8bd959213 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T02:16:53Z |
| publishDate | 2002 |
| record_format | dspace |
| spelling | oxford-uuid:a28de22e-43a4-4844-a39e-a2f8bd9592132022-03-27T02:20:54ZHLA-DR/DQ haplotype in rheumatoid arthritis: novel allelic associations in UK Caucasians.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:a28de22e-43a4-4844-a39e-a2f8bd959213EnglishSymplectic Elements at Oxford2002Milicic, ALee, DBrown, MDarke, CWordsworth, B OBJECTIVE: To elucidate the relative importance of the HLA-DR and HLA-DQ loci in conferring genetic predisposition to rheumatoid arthritis (RA). METHODS: HLA-DRB1 and HLA-DQB1 alleles were typed in a set of 685 patients with RA using sequence-specific polymerase chain reaction. Allele and phenotype frequencies were compared with those in 2 large sets of historical, ethnically matched healthy controls, using the relative predispositional effect method. RESULTS: Positive association was confirmed with the shared epitope positive HLA-DRB1 alleles associated with RA in Caucasians. A significant susceptibility effect was observed with HLA-DRB1*09, described in other ethnically diverse populations but not in Caucasians. A significant underrepresentation of the HLA-DRB1*0103 variant was noted among the RA cases, supporting the proposed protective role of the DERAA motif at residues 70-74 of the DRbeta molecule. No HLA-DRB1 independent association of the HLA-DQB1 alleles, implicated in predisposing to RA, was evident. CONCLUSION: These data corroborate the shared epitope hypothesis of susceptibility to RA and provide strong evidence for the DRB1 locus as the primary RA susceptibility factor in the HLA region. |
| spellingShingle | Milicic, A Lee, D Brown, M Darke, C Wordsworth, B HLA-DR/DQ haplotype in rheumatoid arthritis: novel allelic associations in UK Caucasians. |
| title | HLA-DR/DQ haplotype in rheumatoid arthritis: novel allelic associations in UK Caucasians. |
| title_full | HLA-DR/DQ haplotype in rheumatoid arthritis: novel allelic associations in UK Caucasians. |
| title_fullStr | HLA-DR/DQ haplotype in rheumatoid arthritis: novel allelic associations in UK Caucasians. |
| title_full_unstemmed | HLA-DR/DQ haplotype in rheumatoid arthritis: novel allelic associations in UK Caucasians. |
| title_short | HLA-DR/DQ haplotype in rheumatoid arthritis: novel allelic associations in UK Caucasians. |
| title_sort | hla dr dq haplotype in rheumatoid arthritis novel allelic associations in uk caucasians |
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