Analysis of the human alpha globin upstream regulatory element (HS-40) in transgenic mice.

Analysis of the human alpha globin upstream regulatory element (HS-40) in transgenic mice.

We have analysed the effect of a 1.4 kb segment of DNA containing the upstream alpha globin regulatory element (HS-40) on human alpha globin gene expression in fetal mice and lines of transgenic mice. High levels of tissue-specific, human alpha mRNA expression were seen in all transgenic animals and...

Deskribapen osoa

Xehetasun bibliografikoak
Egile Nagusiak:	Sharpe, J, Chan-Thomas, P, Lida, J, Ayyub, H, Wood, W, Higgs, D
Formatua:	Journal article
Hizkuntza:	English
Argitaratua:	1992

Antzeko izenburuak

Chromosome looping at the human alpha-globin locus is mediated via the major upstream regulatory element (HS -40).
nork: Vernimmen, D, et al.
Argitaratua: (2009)

Deletion of the mouse alpha-globin regulatory element (HS -26) has an unexpectedly mild phenotype.
nork: Anguita, E, et al.
Argitaratua: (2002)

Deletion of the mouse alpha globin regulatory element (HS-26) has an unexpectedly mild phenotype.
nork: Anguita, E, et al.
Argitaratua: (2003)

The mouse alpha-globin locus regulatory element.
nork: Gourdon, G, et al.
Argitaratua: (1995)

Contrasting effects of alpha and beta globin regulatory elements on chromatin structure may be related to their different chromosomal environments.
nork: Craddock, C, et al.
Argitaratua: (1995)

Analysis of the human alpha-globin gene cluster in transgenic mice.
nork: Sharpe, J, et al.
Argitaratua: (1993)

Does Transcription of Remote alpha-Globin Regulatory Elements Affect Their Function?
nork: Kowalczyk, MS, et al.
Argitaratua: (2009)

Alpha-thalassemia caused by a large (62 kb) deletion upstream of the human alpha globin gene cluster.
nork: Hatton, C, et al.
Argitaratua: (1990)

A novel deletion causing alpha thalassemia clarifies the importance of the major human alpha globin regulatory element.
nork: Viprakasit, V, et al.
Argitaratua: (2006)

Role of upstream DNase I hypersensitive sites in the regulation of human alpha globin gene expression.
nork: Sharpe, J, et al.
Argitaratua: (1993)

The mechanism of alpha-globin activation during erythropoiesis
nork: Higgs, D, et al.
Argitaratua: (2007)

The role of distal regulatory elements in alpha globin transcription
nork: Hay, D
Argitaratua: (2014)

Interplay between DNA and histone methylation at an alpha-globin gene silenced by antisense RNA
nork: De Gobbi, M, et al.
Argitaratua: (2007)

Expression of the human alpha-globin cluster in the absence of the major regulatory element Mcs-R2
nork: Badat, M, et al.
Argitaratua: (2018)

Analysis of DNA Methylation at the Human Alpha Globin Cluster during Hematopoiesis
nork: Ekwattanakit, S, et al.
Argitaratua: (2008)

Molecular rearrangements of the human alpha-globin gene cluster.
nork: Higgs, D, et al.
Argitaratua: (1985)

Long-range regulation of alpha-globin gene expression.
nork: Higgs, D, et al.
Argitaratua: (2008)

De novo deletion within the telomeric region flanking the human alpha globin locus as a cause of alpha thalassaemia.
nork: Viprakasit, V, et al.
Argitaratua: (2003)

Conservation of position and sequence of a novel, widely expressed gene containing the major human alpha-globin regulatory element.
nork: Vyas, P, et al.
Argitaratua: (1995)

GEOGRAPHIC-DISTRIBUTION OF ALPHA-GLOBIN AND BETA-GLOBIN GENE-CLUSTER POLYMORPHISMS
nork: Wainscoat, J, et al.
Argitaratua: (1989)

Long-range regulation of alpha globin gene expression during erythropoiesis.
nork: Higgs, D, et al.
Argitaratua: (2008)

Comparative genome analysis delimits a chromosomal domain and identifies key regulatory elements in the alpha globin cluster.
nork: Flint, J, et al.
Argitaratua: (2001)

Proximal promoter elements of the human zeta-globin gene confer embryonic-specific expression on a linked reporter gene in transgenic mice.
nork: Pondel, MD, et al.
Argitaratua: (1996)

Tissue-specific histone modification and transcription factor binding in alpha globin gene expression.
nork: De Gobbi, M, et al.
Argitaratua: (2007)

Alpha globin genotypes in two North European populations.
nork: Flint, J, et al.
Argitaratua: (1986)

A 16.5 kb deletion in the alpha globin cluster associated with an extremely mild phenotype
nork: Rugless, M, et al.
Argitaratua: (2007)

Analysis of the human alpha-globin gene cluster reveals a highly informative genetic locus.
nork: Higgs, D, et al.
Argitaratua: (1986)

Differences in the patterns of transcription factor binding in the human and mouse alpha globin clusters point to potential differences in their regulation.
nork: De Gobbi, M, et al.
Argitaratua: (2005)

Cis-acting sequences regulating expression of the human alpha-globin cluster lie within constitutively open chromatin.
nork: Vyas, P, et al.
Argitaratua: (1992)

A large deletion in the human alpha-globin cluster caused by a replication error is associated with an unexpectedly mild phenotype.
nork: Rugless, M, et al.
Argitaratua: (2008)

The role of the polycomb complex in silencing alpha-globin gene expression in nonerythroid cells.
nork: Garrick, D, et al.
Argitaratua: (2008)

5'HS5 of the human beta-globin locus control region is dispensable for the formation of the beta-globin active chromatin hub.
nork: Ping Kei Chan, et al.
Argitaratua: (2008-01-01)

Deletion of the alpha-globin gene cluster as a cause of acquired alpha-thalassemia in myelodysplastic syndrome.
nork: Steensma, D, et al.
Argitaratua: (2004)

Identification of a conserved erythroid specific domain of histone acetylation across the alpha-globin gene cluster.
nork: Anguita, E, et al.
Argitaratua: (2001)

Regulation of human embryonic globin genes zeta 2 and epsilon in stably transformed mouse erythroleukemia cells.
nork: Vyas, P, et al.
Argitaratua: (1992)

The LCR-like alpha-globin positive regulatory element functions as an enhancer in transiently transfected cells during erythroid differentiation.
nork: Pondel, MD, et al.
Argitaratua: (1992)

DNA looping in the alpha-globin locus
nork: Canals-Hamann, A, et al.
Argitaratua: (2007)

The structure of a human alpha-globin pseudogene and its relationship to alpha-globin gene duplication.
nork: Proudfoot, N, et al.
Argitaratua: (1980)

High-level, erythroid-specific expression of the human alpha-globin gene in transgenic mice and the production of human hemoglobin in murine erythrocytes.
nork: Hanscombe, O, et al.
Argitaratua: (1989)

The role of histone deacetylases in repressing alpha-globin gene expression in non-erythroid cells.
nork: Garrick, D, et al.
Argitaratua: (2003)