Intracellular immunization against HIV infection with an intracellular antibody that mimics HIV integrase binding to the cellular LEDGF protein

Intracellular immunization against HIV infection with an intracellular antibody that mimics HIV integrase binding to the cellular LEDGF protein

Preventing the protein-protein interaction of the cellular chromatin binding protein Lens Epithelium- Derived Growth Factor (LEDGF) and human immunodeficiency virus (HIV) integrase is an important possible strategy for anti-viral treatment for AIDS. We have used Intracellular Antibody Capture techno...

Full description

Bibliographic Details
Main Authors:	Bao, L, Hannon, C, Cruz-Mignoni, A, Ptchelkine, D, Sun, M, Miller, A, Bunjobpol, W, Quevedo, C, Derveni, M, Chambers, J, Simmons, A, Phillips, S, Rabbitts, T
Format:	Journal article
Published:	Nature Publishing Group 2017

Similar Items

HIV-1 integrase modulates the interaction of the HIV-1 cellular cofactor LEDGF/p75 with chromatin
by: Garcia-Rivera Jose A, et al.
Published: (2011-04-01)

The selection of single-domain antibody fragments (iDAbs) by intracellular antibody capture in yeast
by: Rabbitts, T, et al.
Published: (2018)

An unusual helix turn helix motif in the catalytic core of HIV-1 integrase binds viral DNA and LEDGF.
by: Hayate Merad, et al.
Published: (2009-01-01)

LEDGIN-mediated Inhibition of Integrase–LEDGF/p75 Interaction Reduces Reactivation of Residual Latent HIV
by: Lenard S. Vranckx, et al.
Published: (2016-06-01)

Molecular modeling study on the allosteric inhibition mechanism of HIV-1 integrase by LEDGF/p75 binding site inhibitors.
by: Weiwei Xue, et al.
Published: (2014-01-01)

A highly potent and safe pyrrolopyridine-based allosteric HIV-1 integrase inhibitor targeting host LEDGF/p75-integrase interaction site.
by: Tatsuya Maehigashi, et al.
Published: (2021-07-01)

Cloning, purification and structure determination of the HIV integrase-binding domain of lens epithelium-derived growth factor
by: Hannon, C, et al.
Published: (2018)

Allosteric Integrase Inhibitor Influences on HIV-1 Integration and Roles of LEDGF/p75 and HDGFL2 Host Factors
by: Parmit Kumar Singh, et al.
Published: (2022-08-01)

Peptides derived from the HIV-1 integrase promote HIV-1 infection and multi-integration of viral cDNA in LEDGF/p75-knockdown cells
by: Loyter Abraham, et al.
Published: (2010-08-01)

Evaluation of a flavonoid library for inhibition of interaction of HIV-1 integrase with human LEDGF/p75 towards a structure–activity relationship
by: Zhi-Hui Yin, et al.
Published: (2022-12-01)

Integrase and integration: biochemical activities of HIV-1 integrase
by: Deprez Eric, et al.
Published: (2008-12-01)

Abstract LB-068: From intracellular antibody fragments to small molecule inhibitors of mutant KRAS
by: Quevedo, C, et al.
Published: (2017)

Gene Therapy for HIV Infections: Intracellular Immunization
by: Alain Piché
Published: (1999-01-01)

The LEDGF/p75 Integrase Binding Domain Interactome Contributes to the Survival, Clonogenicity, and Tumorsphere Formation of Docetaxel-Resistant Prostate Cancer Cells
by: Greisha L. Ortiz-Hernandez, et al.
Published: (2021-10-01)

Intracellular Antibodies for Drug Discovery and as Drugs of the Future
by: T. H. Rabbitts
Published: (2023-03-01)

Small molecule inhibitors of the LEDGF site of human immunodeficiency virus integrase identified by fragment screening and structure based design.
by: Thomas S Peat, et al.
Published: (2012-01-01)

Structural and functional role of INI1 and LEDGF in the HIV-1 preintegration complex.
by: Benoit Maillot, et al.
Published: (2013-01-01)

Intracellular antibody capture technology: application to selection of intracellular antibodies recognising the BCR-ABL oncogenic protein.
by: Tse, E, et al.
Published: (2002)

LEDGF/p75 proteins with alternative chromatin tethers are functional HIV-1 cofactors.
by: Anne M Meehan, et al.
Published: (2009-07-01)

Changes in the accessibility of the HIV-1 Integrase C-terminus in the presence of cellular proteins
by: Zanta-Boussif Maria-Antonietta, et al.
Published: (2010-04-01)

Modeling HIV-1 intracellular replication : two simulation approaches
by: Zarrabi, Narges., et al.
Published: (2013)

Correction: Small Molecule Inhibitors of the LEDGF Site of Human Immunodeficiency Virus Integrase Identified by Fragment Screening and Structure Based Design.
by: Thomas S. Peat, et al.
Published: (2013-01-01)

Intracellular antibodies and challenges facing their use as therapeutic agents.
by: Lobato, M, et al.
Published: (2003)

Multimodal Functionalities of HIV-1 Integrase
by: Alan N. Engelman, et al.
Published: (2022-04-01)

Intracellular antibody capture (IAC) methods for single domain antibodies.
by: Tanaka, T, et al.
Published: (2012)

Cancer cell killing by target antigen engagement with engineered complementary intracellular antibody single domains fused to pro-caspase3
by: Chambers, J, et al.
Published: (2019)

LEDGF/p75 Deficiency Increases Deletions at the HIV-1 cDNA Ends
by: Murilo T. D. Bueno, et al.
Published: (2017-09-01)

Virus evolution reveals an exclusive role for LEDGF/p75 in chromosomal tethering of HIV.
by: Anneleen Hombrouck, et al.
Published: (2007-03-01)

Integrase-RNA interactions underscore the critical role of integrase in HIV-1 virion morphogenesis
by: Jennifer L Elliott, et al.
Published: (2020-09-01)

Intracellular Defenses Against HIV, Viral Evasion and Novel Therapeutic Approaches
by: Robert A Lever, et al.
Published: (2011-06-01)

Posttranslational Modifications of HIV-1 Integrase by Various Cellular Proteins during Viral Replication
by: Yingfeng Zheng, et al.
Published: (2013-07-01)

Correction: Small Molecule Inhibitors of the LEDGF Site of Human Immunodeficiency Virus Integrase Identified by Fragment Screening and Structure Based Design
Published: (2013-01-01)

De novo production of diverse intracellular antibody libraries.
by: Tanaka, T, et al.
Published: (2003)

Proctitis Caused by Mycobacterium avium-intracellulare in an HIV-Infected Patient
by: Jose Armando Gonzales Zamora, et al.
Published: (2018-05-01)

Prophylaxis against the Mycobacterium avium-intracellulare complex in patients with HIV
by: Julio Maquera-Afaray, et al.
Published: (2018-04-01)

Chromosomal translocation products engender new intracellular therapeutic technologies.
by: Rabbitts, T, et al.
Published: (2003)

Intrabodies based on intracellular capture frameworks that bind the RAS protein with high affinity and impair oncogenic transformation.
by: Tanaka, T, et al.
Published: (2003)

HIV Viral Dynamic under Treatment with Intracellular Delay and Virus Decay as Interactive Parameters
by: R. A. C. Prata, et al.
Published: (2021-06-01)

Dihydroxyphenyl- and Heteroaromatic-Based Thienopyrimidinones to Tackle HIV-1 LEDGF/p75-Dependent IN Activity
by: Graziella Tocco, et al.
Published: (2023-09-01)

Raltegravir: first in class HIV integrase inhibitor
by: Zelalem Temesgen, et al.
Published: (2008-06-01)