Modulation of the hypoxic response in cancer; inhibition of the HIF-1α/p300 protein-protein interaction
<p>Hypoxia inducible factor (HIF)-1α is a heterodimerically-activated transcription factor central to the cellular response to hypoxic environments and is often upregulated in cancer. Binding of HIF-1α to the co-activator p300 is necessary for the hypoxia-induced transcription of many oncogeni...
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| Formaat: | Thesis |
| Taal: | English |
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2014
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