The NUCKS1-SKP2-p21/p27 axis controls S phase entry

Efficient entry into S phase of the cell cycle is necessary for embryonic development and tissue homoeostasis. However, unscheduled S phase entry triggers DNA damage and promotes oncogenesis, underlining the requirement for strict control. Here, we identify the NUCKS1-SKP2-p21/p27 axis as a checkpoi...

Full description

Bibliographic Details
Main Authors: Hume, S, Grou, CP, Lascaux, P, D'Angiolella, V, Legrand, AJ, Ramadan, K, Dianov, GL
Format: Journal article
Language:English
Published: Springer Nature 2021