Rare variant hypothesis for multifactorial inheritance: susceptibility to colorectal adenomas as a model.
The rare variant hypothesis postulates that genetic susceptibility to colorectal neoplasia within the general population is due to a number of low frequency variants in a variety of different genes. Each variant confers a moderate, but detectable, increase in relative risk of developing the disease....
| Main Authors: | , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
2005
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