BACH2 immunodeficiency illustrates an association between super-enhancers and haploinsufficiency

The transcriptional programs that guide lymphocyte differentiation depend on the precise expression and timing of transcription factors (TFs). The TF BACH2 is essential for T and B lymphocytes and is associated with an archetypal super-enhancer (SE). Single-nucleotide variants in the BACH2 locus are...

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Main Authors:	Afzali, B, Grönholm, J, Vandrovcova, J, O'Brien, C, Sun, H, Vanderleyden, I, Davis, F, Khoder, A, Zhang, Y, Hegazy, A, Villarino, A, Palmer, I, Kaufman, J, Watts, N, Kazemian, M, Kamenyeva, O, Keith, J, Sayed, A, Kasperaviciute, D, Mueller, M, Hughes, J, Fuss, I, Sadiyah, M, Montgomery-Recht, K, McElwee, J, Restifo, N, Strober, W, Linterman, M, Wingfield, P, Uhlig, H, Roychoudhuri, R, Aitman, T, Kelleher, P, Lenardo, M, O'Shea, J, Cooper, N, Laurence, A
פורמט:	Journal article
שפה:	English
יצא לאור:	Springer Nature 2017

BACH2 immunodeficiency illustrates an association between super-enhancers and haploinsufficiency

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