The calcium-mobilizing messenger nicotinic acid adenine dinucleotide phosphate participates in sperm activation by mediating the acrosome reaction.

Before a sperm can fertilize an egg it must undergo a final activation step induced by the egg termed the acrosome reaction. During the acrosome reaction a lysosome-related organelle, the acrosome, fuses with the plasma membrane to release hydrolytic enzymes and expose an egg-binding protein. Becaus...

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Bibliographic Details
Main Authors: Vasudevan, SR, Lewis, A, Chan, J, Machin, C, Sinha, D, Galione, A, Churchill, G
Format: Journal article
Language:English
Published: 2010