Ribozymes as therapeutic tools for genetic disease.

Ribozymes as therapeutic tools for genetic disease.

The discovery that RNA can act as a biological catalyst, as well as a genetic molecule, indicated that there was a time when biological reactions were catalysed in the absence of protein-based enzymes. It also provided the platform to develop those catalytic RNA molecules, called ribozymes, as trans...

Disgrifiad llawn

Manylion Llyfryddiaeth
Prif Awduron:	Phylactou, L, Kilpatrick, M, Wood, M
Fformat:	Journal article
Iaith:	English
Cyhoeddwyd:	1998

Eitemau Tebyg

Ribozyme-mediated trans-splicing of a trinucleotide repeat.
gan: Phylactou, L, et al.
Cyhoeddwyd: (1998)

The Application of Ribozymes and DNAzymes in Muscle and Brain
gan: Leonidas A. Phylactou, et al.
Cyhoeddwyd: (2010-08-01)

Hammerhead ribozymes reduce central nervous system (CNS)-derived neuronal nitric oxide synthase messenger RNA in a human cell line.
gan: Maniotis, D, et al.
Cyhoeddwyd: (2002)

Ribozymes and siRNA for the treatment of diseases of the nervous system.
gan: Wood, M, et al.
Cyhoeddwyd: (2003)

Expanding the limits of the second genetic code with ribozymes
gan: Joongoo Lee, et al.
Cyhoeddwyd: (2019-11-01)

Ribozymes and RNA catalysis /
gan: Lilley, David M. J. David Malcolm James, 1948-, et al.
Cyhoeddwyd: (2008)

[RNA polymerase ribozymes]
gan: Lawrence, Michael S. (Michael Scott), 1975-
Cyhoeddwyd: (2008)

Ribozymes : methods and protocols /
gan: Hartig, Jr̲g S.
Cyhoeddwyd: (2012)

Arginine cofactors on the polymerase ribozyme.
gan: Chengguo Yao, et al.
Cyhoeddwyd: (2011-01-01)

A reverse transcriptase ribozyme
gan: Biswajit Samanta, et al.
Cyhoeddwyd: (2017-09-01)

Special Issue: Ribozymes and RNA Catalysis
gan: Sabine Müller
Cyhoeddwyd: (2017-05-01)

Man versus machine versus ribozyme.
gan: Andrew D Ellington
Cyhoeddwyd: (2008-05-01)

Searching for ribozymes with new and improved properties
gan: Curtis, Edward A. (Edward Arthur)
Cyhoeddwyd: (2007)

Ribozyme-based insulator parts buffer synthetic circuits from genetic context
gan: Lou, Chunbo, et al.
Cyhoeddwyd: (2014)

A Singular and Widespread Group of Mobile Genetic Elements: RNA Circles with Autocatalytic Ribozymes
gan: Marcos de la Peña, et al.
Cyhoeddwyd: (2020-11-01)

The use of ribozymes in gene therapy approaches to AIDS.
gan: James, W
Cyhoeddwyd: (1998)

Computational approaches to the identification of ribozyme target sites.
gan: James, W, et al.
Cyhoeddwyd: (1997)

Inhibition of telomerase activity by HDV ribozyme in cancers
gan: Gao Yanjing, et al.
Cyhoeddwyd: (2011-01-01)

Structure, dynamics, and mechanism of the lead-dependent ribozyme
gan: Qi Xin, et al.
Cyhoeddwyd: (2011-08-01)

Viroid Replication: Rolling-Circles, Enzymes and Ribozymes
gan: Marcos De la Peña, et al.
Cyhoeddwyd: (2009-09-01)

Engineering RNA logic with synthetic splicing ribozymes
gan: Che, Austin, 1979-
Cyhoeddwyd: (2009)

Use of 33P for Ribozyme Assays: The Safe Way
gan: Patrice R.A. Wolff, et al.
Cyhoeddwyd: (1996-09-01)

Fluorescence Polarization for Monitoring Ribozyme Reactions in Real Time
gan: K.K. Singh, et al.
Cyhoeddwyd: (2000-08-01)

RNA ligase ribozymes with a small catalytic core
gan: Yoko Nomura, et al.
Cyhoeddwyd: (2023-05-01)

Modulation of Group I Ribozyme Activity by Cationic Porphyrins
gan: Shigeyoshi Matsumura, et al.
Cyhoeddwyd: (2015-03-01)

Molecular Crowding Facilitates Ribozyme-Catalyzed RNA Assembly
gan: Saurja DasGupta, et al.
Cyhoeddwyd: (2023-08-01)

RiboaptDB: A Comprehensive Database of Ribozymes and Aptamers
gan: Thodima Venkata, et al.
Cyhoeddwyd: (2006-09-01)

Emergent properties as by-products of prebiotic evolution of aminoacylation ribozymes
gan: Evan Janzen, et al.
Cyhoeddwyd: (2022-06-01)

Design principles for ligand-sensing, conformation-switching ribozymes.
gan: Xi Chen, et al.
Cyhoeddwyd: (2009-12-01)

Prebiotic Factors Influencing the Activity of a Ligase Ribozyme
gan: Fabrizio Anella, et al.
Cyhoeddwyd: (2017-04-01)

Structural and Biochemical Properties of Novel Self-Cleaving Ribozymes
gan: Ki-Young Lee, et al.
Cyhoeddwyd: (2017-04-01)

Kinetic barriers to folding in the Tetrahymena group I ribozyme
gan: Rook, Martha S. (Martha Sanderson), 1970-
Cyhoeddwyd: (2009)

OPTIMIZING HAMMERHEAD RIBOZYMES FOR USE AGAINST HIV IN-VIVO
gan: Thompson, S, et al.
Cyhoeddwyd: (1995)

RNA Synthesis by in Vitro Selected Ribozymes for Recreating an RNA World
gan: Lyssa L. Martin, et al.
Cyhoeddwyd: (2015-01-01)

Many Activities, One Structure: Functional Plasticity of Ribozyme Folds
gan: Matthew W.L. Lau, et al.
Cyhoeddwyd: (2016-11-01)

An RNA Triangle with Six Ribozyme Units Can Promote a <i>Trans</i>-Splicing Reaction through Trimerization of Unit Ribozyme Dimers
gan: Junya Akagi, et al.
Cyhoeddwyd: (2021-03-01)

The structure and catalytic mechanism of a pseudoknot-containing hammerhead ribozyme
gan: Xuelin Zhan, et al.
Cyhoeddwyd: (2024-08-01)

Quantitation of In Vitro Activity of Synthetic Trans-Acting Ribozymes Using HPLC
gan: L. Citti, et al.
Cyhoeddwyd: (1997-11-01)

Development of Allosteric Ribozymes for ATP and <span style="font-variant: small-caps">l</span>-Histidine Based on the R3C Ligase Ribozyme
gan: Yuna Akatsu, et al.
Cyhoeddwyd: (2024-04-01)

Selective cleavage of AChR cRNAs harbouring mutations underlying the slow channel myasthenic syndrome by hammerhead ribozymes.
gan: Abdelgany, A, et al.
Cyhoeddwyd: (2005)