Molecular mechanisms of fibrillogenesis and the protective role of amyloid P component: two possible avenues for therapy.

Amyloid deposits regress when the supply of fibril precursor proteins is sufficiently reduced, indicating that amyloid fibrils are degradable in vivo. Serum amyloid P component (SAP), a universal constituent of amyloid deposits, efficiently protects amyloid fibrils from proteolysis in vitro, and may...

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Main Authors:	Pepys, M, Tennent, G, Booth, DR, Bellotti, V, Lovat, L, Tan, S, Persey, MR, Hutchinson, W, Booth, SE, Madhoo, S, Soutar, A, Hawkins, P, Van Zyl-Smit, R, Campistol, J, Fraser, P, Radford, SE, Robinson, C, Sunde, M, Serpell, L, Blake, C
Format:	Journal article
Language:	English
Published:	1996

Molecular mechanisms of fibrillogenesis and the protective role of amyloid P component: two possible avenues for therapy.

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