CTLA4 gene polymorphism and autoimmunity.
CD28 and cytotoxic T-lymphocyte antigen-4 (CTLA4) are two receptors that have critical but opposing functions in T-cell stimulation. CD28 promotes a number of T-cell activities, whereas in contrast CTLA4 is an essential inhibitor of T-cell responses. Because of its inhibitory role, CTLA4 is a strong...
| Main Authors: | , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
2005
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