Interleukin-1 acts via the JNK-2 signaling pathway to induce aggrecan degradation by human chondrocytes

<br xmlns:etd="http://www.ouls.ox.ac.uk/ora/modsextensions"><strong>Objective: </strong>Aggrecan enables articular cartilage to bear load and resist compression. Aggrecan loss occurs early in osteoarthritis and rheumatoid arthritis and can be induced by inflammatory cytok...

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Detalles Bibliográficos
Main Authors: Ismail, H, Yamamoto, K, Vincent, T, Nagase, H, Troeberg, L, Saklatvala, J
Formato: Journal article
Idioma:English
Publicado: Wiley 2015