Interleukin-1 acts via the JNK-2 signaling pathway to induce aggrecan degradation by human chondrocytes

<br xmlns:etd="http://www.ouls.ox.ac.uk/ora/modsextensions"><strong>Objective: </strong>Aggrecan enables articular cartilage to bear load and resist compression. Aggrecan loss occurs early in osteoarthritis and rheumatoid arthritis and can be induced by inflammatory cytok...

ver descrição completa

Detalhes bibliográficos
Principais autores: Ismail, H, Yamamoto, K, Vincent, T, Nagase, H, Troeberg, L, Saklatvala, J
Formato: Journal article
Idioma:English
Publicado em: Wiley 2015

Registros relacionados