A regulatory role for TGF-β signaling in the establishment and function of the thymic medulla.
Medullary thymic epithelial cells (mTECs) are critical in establishing and maintaining the appropriate microenvironment for negative selection and maturation of immunocompetent T cells with a self-tolerant T cell antigen receptor repertoire. Cues that direct proliferation and maturation of mTECs are...
| Main Authors: | , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
2014
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