Crystal structures of HIV-1 reverse transcriptases mutated at codons 100, 106 and 108 and mechanisms of resistance to non-nucleoside inhibitors.

Leu100Ile, Val106Ala and Val108Ile are mutations in HIV-1 reverse transcriptase (RT) that are observed in the clinic and give rise to resistance to certain non-nucleoside inhibitors (NNRTIs) including the first-generation drug nevirapine. In order to investigate structural mechanisms of resistance f...

詳細記述

書誌詳細
主要な著者: Ren, J, Nichols, C, Chamberlain, P, Weaver, K, Short, SA, Stammers, D
フォーマット: Journal article
言語:English
出版事項: 2004