Crystal structures of HIV-1 reverse transcriptases mutated at codons 100, 106 and 108 and mechanisms of resistance to non-nucleoside inhibitors.

Crystal structures of HIV-1 reverse transcriptases mutated at codons 100, 106 and 108 and mechanisms of resistance to non-nucleoside inhibitors.

Leu100Ile, Val106Ala and Val108Ile are mutations in HIV-1 reverse transcriptase (RT) that are observed in the clinic and give rise to resistance to certain non-nucleoside inhibitors (NNRTIs) including the first-generation drug nevirapine. In order to investigate structural mechanisms of resistance f...

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Bibliografiska uppgifter
Huvudupphovsmän:	Ren, J, Nichols, C, Chamberlain, P, Weaver, K, Short, SA, Stammers, D
Materialtyp:	Journal article
Språk:	English
Publicerad:	2004

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