The prognostic and therapeutic implications of distinct patterns of argininosuccinate synthase 1 (ASS1) and arginase-2 (ARG2) expression by cancer cells and tumor stroma in non-small-cell lung cancer

<p><strong>Background</strong></p> <p>Arginine (Arg) is essential for cancer cell growth and also for the activation of T cells. Thus, therapies aiming to reduce Arg utilization by cancer may prove detrimental for the immune response.</p></br> <p><...

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Bibliographic Details
Main Authors: Giatromanolaki, A, Harris, AL, Koukourakis, MI
Format: Journal article
Language:English
Published: BioMed Central 2021