Stable recombination hotspots in birds
The DNA-binding protein PRDM9 has a critical role in specifying meiotic recombination hotspots in mice and apes, but it appears to be absent from other vertebrate species, including birds. To study the evolution and determinants of recombination in species lacking the gene that encodes PRDM9, we inf...
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Journal article |
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American Association for the Advancement of Science
2015
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| _version_ | 1826289161797107712 |
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| author | Singhal, S Leffler, E Sannareddy, K Turner, I Venn, O Hooper, D Strand, A Li, Q Raney, B Balakrishnan, C Griffith, S McVean, G Przeworski, M |
| author_facet | Singhal, S Leffler, E Sannareddy, K Turner, I Venn, O Hooper, D Strand, A Li, Q Raney, B Balakrishnan, C Griffith, S McVean, G Przeworski, M |
| author_sort | Singhal, S |
| collection | OXFORD |
| description | The DNA-binding protein PRDM9 has a critical role in specifying meiotic recombination hotspots in mice and apes, but it appears to be absent from other vertebrate species, including birds. To study the evolution and determinants of recombination in species lacking the gene that encodes PRDM9, we inferred fine-scale genetic maps from population resequencing data for two bird species: the zebra finch, Taeniopygia guttata, and the long-tailed finch, Poephila acuticauda. We found that both species have recombination hotspots, which are enriched near functional genomic elements. Unlike in mice and apes, most hotspots are shared between the two species, and their conservation seems to extend over tens of millions of years. These observations suggest that in the absence of PRDM9, recombination targets functional features that both enable access to the genome and constrain its evolution. |
| first_indexed | 2024-03-07T02:24:41Z |
| format | Journal article |
| id | oxford-uuid:a53084d3-60c9-4cdd-9a0c-c551acc83964 |
| institution | University of Oxford |
| last_indexed | 2024-03-07T02:24:41Z |
| publishDate | 2015 |
| publisher | American Association for the Advancement of Science |
| record_format | dspace |
| spelling | oxford-uuid:a53084d3-60c9-4cdd-9a0c-c551acc839642022-03-27T02:38:42ZStable recombination hotspots in birdsJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:a53084d3-60c9-4cdd-9a0c-c551acc83964Symplectic Elements at OxfordAmerican Association for the Advancement of Science2015Singhal, SLeffler, ESannareddy, KTurner, IVenn, OHooper, DStrand, ALi, QRaney, BBalakrishnan, CGriffith, SMcVean, GPrzeworski, MThe DNA-binding protein PRDM9 has a critical role in specifying meiotic recombination hotspots in mice and apes, but it appears to be absent from other vertebrate species, including birds. To study the evolution and determinants of recombination in species lacking the gene that encodes PRDM9, we inferred fine-scale genetic maps from population resequencing data for two bird species: the zebra finch, Taeniopygia guttata, and the long-tailed finch, Poephila acuticauda. We found that both species have recombination hotspots, which are enriched near functional genomic elements. Unlike in mice and apes, most hotspots are shared between the two species, and their conservation seems to extend over tens of millions of years. These observations suggest that in the absence of PRDM9, recombination targets functional features that both enable access to the genome and constrain its evolution. |
| spellingShingle | Singhal, S Leffler, E Sannareddy, K Turner, I Venn, O Hooper, D Strand, A Li, Q Raney, B Balakrishnan, C Griffith, S McVean, G Przeworski, M Stable recombination hotspots in birds |
| title | Stable recombination hotspots in birds |
| title_full | Stable recombination hotspots in birds |
| title_fullStr | Stable recombination hotspots in birds |
| title_full_unstemmed | Stable recombination hotspots in birds |
| title_short | Stable recombination hotspots in birds |
| title_sort | stable recombination hotspots in birds |
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