Structure-activity relationships of human AKR-type oxidoreductases involved in bile acid synthesis: AKR1D1 and AKR1C4.

Structure-activity relationships of human AKR-type oxidoreductases involved in bile acid synthesis: AKR1D1 and AKR1C4.

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Two members of the human aldo-keto reductase (AKR) superfamily participate in the biosynthesis of bile acids by catalyzing the NADP(H) dependent reduction of 3-keto groups (AKR1C4) and Delta4 double bonds (AKR1D1) of oxysterol precursors. Structure determination of human AKR1C4 and homology modellin...

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Bibliographic Details
Main Authors:	Lee, W, Lukacik, P, Guo, K, Ugochukwu, E, Kavanagh, K, Marsden, B, Oppermann, U
Format:	Journal article
Language:	English
Published:	2009
Subjects:	biosynthesis Tryptophan Crystallography, X-Ray Structural Homology, Protein Humans Catalytic Domain metabolism Oxidoreductases Ligands Models, Molecular chemistry Structure-Activity Relationship Bile Acids and Salts

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