Structure-activity relationships of human AKR-type oxidoreductases involved in bile acid synthesis: AKR1D1 and AKR1C4.

Structure-activity relationships of human AKR-type oxidoreductases involved in bile acid synthesis: AKR1D1 and AKR1C4.

Show other versions (1)

Two members of the human aldo-keto reductase (AKR) superfamily participate in the biosynthesis of bile acids by catalyzing the NADP(H) dependent reduction of 3-keto groups (AKR1C4) and Delta4 double bonds (AKR1D1) of oxysterol precursors. Structure determination of human AKR1C4 and homology modellin...

Deskribapen osoa

Xehetasun bibliografikoak
Egile Nagusiak:	Lee, W, Lukacik, P, Guo, K, Ugochukwu, E, Kavanagh, K, Marsden, B, Oppermann, U
Formatua:	Journal article
Hizkuntza:	English
Argitaratua:	2009
Gaiak:	biosynthesis Tryptophan Crystallography, X-Ray Structural Homology, Protein Humans Catalytic Domain metabolism Oxidoreductases Ligands Models, Molecular chemistry Structure-Activity Relationship Bile Acids and Salts

Antzeko izenburuak

Structure-activity relationships of human AKR-type oxidoreductases involved in bile acid synthesis: AKR1D1 and AKR1C4.
nork: Lee, W, et al.
Argitaratua: (2009)

Enzymes of the AKR1B and AKR1C subfamilies and uterine diseases
nork: Tea eLanisnik Rizner
Argitaratua: (2012-03-01)

Ruthenium complexes show potent inhibition of AKR1C1, AKR1C2, and AKR1C3 enzymes and anti-proliferative action against chemoresistant ovarian cancer cell line
nork: Jakob Kljun, et al.
Argitaratua: (2022-08-01)

Expression of the Aldo-Keto Reductases AKR1B1 and AKR1B10 in Human Cancers.
nork: Brian eLaffin, et al.
Argitaratua: (2012-06-01)

Roles of AKR1C3 in malignancy
nork: Xin-Zhu Xiao, et al.
Argitaratua: (2021-05-01)

Modeling single nucleotide polymorphisms in the human AKR1C1 and AKR1C2 genes: implications for functional and genotyping analyses.
nork: Jonathan W Arthur, et al.
Argitaratua: (2010-12-01)

INCREASED EXPRESSION OF AKR1C2 AND AKR1B1 GENES IS ASSOCIATED WITH THE DEVELOPMENT OF RESISTANCE TO DOCETAXEL IN PROSTATE CANCER
nork: Pudova Е.A.
Argitaratua: (2023-11-01)

In-silico Investigations of quinine and quinidine as potential Inhibitors of AKR1B1 and AKR1B10: Functional and structural characterization.
nork: Syeda Abida Ejaz, et al.
Argitaratua: (2022-01-01)

Expression of progesterone metabolizing enzyme genes (AKR1C1, AKR1C2, AKR1C3, SRD5A1, SRD5A2) is altered in human breast carcinoma
nork: Wiebe John P, et al.
Argitaratua: (2004-06-01)

The Role of AKR1B10 in Physiology and Pathophysiology
nork: Satoshi Endo, et al.
Argitaratua: (2021-05-01)

Pleiotropic Actions of Aldehyde Reductase (AKR1A)
nork: Junichi Fujii, et al.
Argitaratua: (2021-05-01)

Human and murine steroid 5β-reductases (AKR1D1 and AKR1D4): Insights into the role of the catalytic glutamic acid
nork: Chen, M, et al.
Argitaratua: (2019)

Unravelling the role of AKR1D1 in human hepatocytes
nork: Nikolaou, N
Argitaratua: (2017)

Gondolatok közigazgatási eljárásjogunk változásairól: Ket. és Ákr. (Reflections on changes in our administrative procedural law: Ket. and Ákr.)
nork: Györgyi Balogh
Argitaratua: (2021-11-01)

BET inhibitors potentiate melanoma ferroptosis and immunotherapy through AKR1C2 inhibition
nork: Yu Meng, et al.
Argitaratua: (2023-12-01)

Space performance assessment of traditional houses in Akre
nork: Kadhim Fathel Khalil, et al.
Argitaratua: (2024-05-01)

The prostaglandin F synthase activity of the human aldose reductase AKR1B1 brings new lenses to look at pathologic conditions.
nork: Eva eBresson, et al.
Argitaratua: (2012-05-01)

AKR1B10 and digestive tumors development: a review
nork: Yao Shen, et al.
Argitaratua: (2024-12-01)

Analogues of Natural Chalcones as Efficient Inhibitors of AKR1C3
nork: Gabriele Möller, et al.
Argitaratua: (2022-01-01)

Glucocorticoids regulate AKR1D1 activity in human liver in vitro and in vivo
nork: Nikolaou, N, et al.
Argitaratua: (2020)

AKR1D1 regulates glucocorticoid availability and glucocorticoid receptor activation in human hepatoma cells.
nork: Nikolaou, N, et al.
Argitaratua: (2019)

AKRs confer oligodendrocytes resistance to differentiation-stimulated ferroptosis
nork: Valentina Saverio, et al.
Argitaratua: (2025-02-01)

Aldo-keto reductase (AKR) superfamily: Genomics and annotation
nork: Mindnich Rebekka D, et al.
Argitaratua: (2009-07-01)

Long read sequencing characterises a novel structural variant, revealing underactive AKR1C1 with overactive AKR1C2 as a possible cause of severe chronic fatigue
nork: Julia Oakley, et al.
Argitaratua: (2023-11-01)

Medium- and short-chain dehydrogenase/reductase gene and protein families : the SDR superfamily: functional and structural diversity within a family of metabolic and regulatory enzymes.
nork: Kavanagh, K, et al.
Argitaratua: (2008)

AKR1C3 in carcinomas: from multifaceted roles to therapeutic strategies
nork: Mengnan Li, et al.
Argitaratua: (2024-03-01)

Expression of AKR1C3 Protein in Human Keloid Skin Tissue
nork: Doo Hyun Nam, et al.
Argitaratua: (2016-02-01)

The expression and significance of AKR1B10 in laryngeal squamous cell carcinoma
nork: Jixuan Liu, et al.
Argitaratua: (2021-09-01)

Discovery of an Aldo-Keto reductase 1C3 (AKR1C3) degrader
nork: Angelica V. Carmona, et al.
Argitaratua: (2024-04-01)

AKR1D1 knockout mice develop a sex-dependent metabolic phenotype
nork: Gathercole, LL, et al.
Argitaratua: (2022)

Relationship of the AKR1B1 rs759853 and rs9640883 with the development of diabetic retinopathy
nork: S.Iu. Mogilevskyy, et al.
Argitaratua: (2017-04-01)

Liquiritin, as a Natural Inhibitor of AKR1C1, Could Interfere With the Progesterone Metabolism
nork: Chenming Zeng, et al.
Argitaratua: (2019-07-01)

In Vitro Analysis of AKR1D1 Interactions with Clopidogrel: Effects on Enzyme Activity and Gene Expression
nork: Shutevska K, et al.
Argitaratua: (2025-03-01)

AKR2A is involved in the flowering process of Arabidopsis thaliana
nork: Qian Tang, et al.
Argitaratua: (2022-12-01)

Electrostatic shock properties inferred from AKR fine structure
nork: R. Pottelette, et al.
Argitaratua: (2003-01-01)

EXPERIMENTAL DETERMINATION OF THE ZERO POWER TRANSFER FUNCTION OF THE AKR-2
nork: Hübner Sebastian, et al.
Argitaratua: (2021-01-01)

Avasimibe Dampens Cholangiocarcinoma Progression by Inhibiting FoxM1-AKR1C1 Signaling
nork: Yunshu Gao, et al.
Argitaratua: (2021-05-01)

Clinical and genetic features of congenital bile acid synthesis defect with a novel mutation in AKR1D1 gene sequencing
nork: Anh-Hoa Nguyen Pham, MD, PhD, et al.
Argitaratua: (2022-06-01)

AKR1D1 and CYP7B1 mutations in patients with inborn errors of bile acid metabolism: Possibly underdiagnosed diseases
nork: Ju-Yin Chen, et al.
Argitaratua: (2020-02-01)

AKR1B1 drives hyperglycemia-induced metabolic reprogramming in MASLD-associated hepatocellular carcinoma
nork: NP Syamprasad, et al.
Argitaratua: (2024-02-01)