Glucokinase activity in diabetes: too much of a good thing?

Type 2 diabetes (T2D) is a global health problem characterised by chronic hyperglycaemia due to inadequate insulin secretion. Because glucose must be metabolised to stimulate insulin release it was initially argued that drugs that stimulate glucokinase (the first enzyme in glucose metabolism) would...

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Bibliographic Details
Main Authors: Ashcroft, FM, Lloyd, M, Haythorne, EA
Format: Journal article
Language:English
Published: Cell Press 2022