Synthesis of [4S‐2H]NADH, [4R‐2H]NADH, [4‐2H2]NADH and [4‐2H]NAD+ cofactors through heterogeneous biocatalysis in heavy water

Synthesis of [4S‐2H]NADH, [4R‐2H]NADH, [4‐2H2]NADH and [4‐2H]NAD+ cofactors through heterogeneous biocatalysis in heavy water

This practitioner protocol describes the synthesis of a family of deuterated nicotinamide cofactors: [4S‐2H]NADH, [4R‐2H]NADH, [4‐2H2]NADH and [4‐2H]NAD+. The application of a recently developed H2‐driven heterogeneous biocatalyst enables the cofactors to be prepared with high (>90%) 2H‐incorpora...

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Main Authors: Rowbotham, JS, Hardy, AP, Reeve, HA, Vincent, KA
格式: Journal article
语言:English
出版: Wiley 2021

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